Please use this identifier to cite or link to this item:
DC FieldValueLanguage
dc.contributor.authorTan, Shi Y.en_US
dc.contributor.authorTan, Irene K. P.en_US
dc.contributor.authorTan, Mui F.en_US
dc.contributor.authorDutta, Avirupen_US
dc.contributor.authorChoo, Siew W.en_US
dc.identifier.citationTan, S. Y., Tan, I. K. P., Tan, M. F., Dutta, A., & Choo, S. W. (2016). Evolutionary study of Yersinia genomes deciphers emergence of human pathogenic species. Scientific Reports, 6, 36116.en_US
dc.description.abstractOn record, there are 17 species in the Yersinia genus, of which three are known to be pathogenic to human. While the chromosomal and pYV (or pCD1) plasmid-borne virulence genes as well as pathogenesis of these three species are well studied, their genomic evolution is poorly understood. Our study aims to predict the key evolutionary events that led to the emergence of pathogenic Yersinia species by analyzing gene gain-and-loss, virulence genes, and “Clustered regularly-interspaced short palindromic repeats”. Our results suggest that the most recent ancestor shared by the human pathogenic Yersinia was most probably an environmental species that had adapted to the human body. This might have led to ecological specialization that diverged Yersinia into ecotypes and distinct lineages based on differential gene gain-and-loss in different niches. Our data also suggest that Y. pseudotuberculosis group might be the donor of the ail virulence gene to Y. enterocolitica. Hence, we postulate that evolution of human pathogenic Yersinia might not be totally in parallel, but instead, there were lateral gene transfer events. Furthermore, the presence of virulence genes seems to be important for the positive selection of virulence plasmid. Our studies provide better insights into the evolutionary biology of these bacteria.en_US
dc.format.extent10 pagesen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofScientific Reportsen_US
dc.titleEvolutionary study of Yersinia genomes deciphers emergence of human pathogenic speciesen_US
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.subject.keywordsYersinia Genusen_US
dc.subject.keywordsGenomic Evolutionen_US
dc.subject.keywordsVirulence Genesen_US
Appears in Collections:Scholarly Publications
Files in This Item:
File Description SizeFormat 
wku_schlrs_publcn_000069.pdf2.68 MBAdobe PDFThumbnail
Show simple item record

Page view(s)

checked on May 29, 2023


checked on May 29, 2023

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons