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Title: Probiotic supplements: Hope or hype?
Authors: Wang, Yuxuan 
Jiang, Yinyin 
Deng, Yuxin 
Yi, Chen 
Wang, Yangcan 
Ding, Mengnan 
Liu, Jie 
Jin, Xuanjing 
Shen, Lishan 
He, Yue 
Wu, Xinyun 
Chen, Xuefei 
Sun, Changyi 
Zheng, Min 
Zhang, Ruijia 
Ye, Hailv 
An, Huiting 
Wong, Aloysius 
Issue Date: 2020
Publisher: Frontiers Media S.A.
Source: Wang, Y., Jiang, Y., Deng, Y., Yi, C., Wang, Y., Ding, M., ... & Wong, A. (2020). Probiotic supplements: Hope or hype?. Frontiers in Microbiology, 11, 160.
Journal: Frontiers in Microbiology 
Abstract: Probiotic bacteria have been associated with various health benefits and included in overwhelming number of foods. Today, probiotic supplements are consumed with increasing regularity and record a rapidly growing economic value. With billions of heterogeneous populations of probiotics per serving, probiotic supplements contain the largest quantity of probiotics across all functional foods. They often carry antibiotic-resistant determinants that can be transferred to and accumulate in resident bacteria of the gastrointestinal tract and risk their acquisitions by opportunistic pathogens. While the health benefits of probiotics have been widely publicized, this health risk, however, is underrepresented in both scientific studies and public awareness. On the other hand, the human gut presents conditions that are unfavorable for bacteria, including probiotics. It remains uncertain if probiotics from supplements can tolerate acids and bile salts that may undermine their effectiveness in conferring health benefits. Here, we put into perspective the perceived health benefits and the long-term safety of consuming probiotic supplements, specifically bringing intolerance to acids and bile salts, and the long-standing issue of antibiotic-resistant gene transfer into sharp focus. We report that probiotics from supplements examined in this study have poor tolerance to acids and bile salts while also displaying resistance to multiple antibiotics. They could also adapt and gain resistance to streptomycin in vitro. In an environment where consuming supplements is considered a norm, our results and that of others will put in perspective the persisting concerns surrounding probiotic supplements so that the current hype does not overpower the hope.
DOI: 10.3389/fmicb.2020.00160
Appears in Collections:Scholarly Publications

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