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Title: Comparative genomic analysis of Mycobacterium iranicum UM_TJL against representative mycobacterial species suggests its environmental origin
Authors: Tan, Joon L. 
Ngeow, Yun F. 
Wee, Wei Y. 
Wong, Guat J. 
Ng, Hien F. 
Choo, Siew W. 
Issue Date: 2014
Publisher: Springer Nature
Source: Tan, J. L., Ngeow, Y. F., Wee, W. Y., Wong, G. J., Ng, H. F., & Choo, S. W. (2014). Comparative genomic analysis of Mycobacterium iranicum UM_TJL against representative mycobacterial species suggests its environmental origin. Scientific Reports, 4, 7169.
Journal: Scientific Reports 
Abstract: Mycobacterium iranicum is a newly reported mycobacterial species. We present the first comparative study of M. iranicum UM_TJL and other mycobacteria. We found M. iranicum to have a close genetic association with environmental mycobacteria infrequently associated with human infections. Nonetheless, UM_TJL is also equipped with many virulence genes (some of which appear to be the consequence of transduction-related gene transfer) that have been identified in established human pathogens. Taken all together, our data suggest that M. iranicum is an environmental bacterium adapted for pathogenicity in the human host. This comparative study provides important clues and forms the basis for future functional studies on this mycobacterium.
DOI: 10.1038/srep07169
Appears in Collections:Scholarly Publications

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