Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12540/104
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dc.contributor.authorChoo, Siew W.en_US
dc.contributor.authorWee, Wei Y.en_US
dc.contributor.authorNgeow, Yun F.en_US
dc.contributor.authorMitchell, Wayneen_US
dc.contributor.authorTan, Joon L.en_US
dc.contributor.authorWong, Guat J.en_US
dc.contributor.authorZhao, Yongbingen_US
dc.contributor.authorXiao, Jingfaen_US
dc.date.accessioned2020-07-21T01:48:14Z-
dc.date.available2020-07-21T01:48:14Z-
dc.date.issued2014-
dc.identifier.citationChoo, S. W., Wee, W. Y., Ngeow, Y. F., Mitchell, W., Tan, J. L., Wong, G. J., ... & Xiao, J. (2014). Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential. Scientific Reports, 4, 4061.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12540/104-
dc.description.abstractMycobacterium abscessus (Ma) is an emerging human pathogen that causes both soft tissue infections and systemic disease. We present the first comparative whole-genome study of Ma strains isolated from patients of wide geographical origin. We found a high proportion of accessory strain-specific genes indicating an open, non-conservative pan-genome structure and clear evidence of rapid phage-mediated evolution. Although we found fewer virulence factors in Ma compared to M. tuberculosis, our data indicated that Ma evolves rapidly and therefore should be monitored closely for the acquisition of more pathogenic traits. This comparative study provides a better understanding of Ma and forms the basis for future functional work on this important pathogen.en_US
dc.format.extent10 pagesen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofScientific Reportsen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/-
dc.subject.lcshComparative Studyen_US
dc.titleGenomic reconnaissance of multiple, clinically isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potentialen_US
dc.typeArticleen_US
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.identifier.doi10.1038/srep04061-
dc.subject.keywordsMycobacterium Abscessusen_US
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